![]() ![]() In recent years, some scholars have proposed the concept of tissue-induced biomaterials that can induce bone regeneration through a scaffold structure without adding cytokines. However, cytokines implanted into the body easily cause an immune response, and the cost is high therefore, the clinical treatment effect is not outstanding. Currently, the application of bone tissue engineering mainly focuses on promoting fracture healing by carrying cytokines. The number of patients with bone defects caused by various bone diseases is increasing yearly in the aging population, and people are paying increasing attention to bone tissue engineering research. 7Department of Orthopedics, Jinhua People’s Hospital, Jinhua, Zhejiang, China.6Department of Traumatology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.5Department of Orthopedics, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China. ![]() 4Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.3The Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, China.2Institute of Clinical Medicine, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.1Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.Jingyu Zhou 1,2,3 †, Shilang Xiong 2,4 †, Min Liu 1,3, Hao Yang 3, Peng Wei 1,2,3, Feng Yi 1,3, Min Ouyang 1,3, Hanrui Xi 1,3, Zhisheng Long 5, Yayun Liu 6, Jingtang Li 6, Linghua Ding 7 and Long Xiong 1* ![]()
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